Communication : Detection and Estimation of Azomethane in Expired Air of l , 2 - Dimethylhydrazine - Treated Rats
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چکیده
Azomethane (AM) gas was identified as a major metabolite of 1,2-dimethylhydrazine (1,2-DMH) in the expired air of F344 rats. The compound was characterized by highpressure liquid chromatography, gas chromatography, and mass spectrometry, in comparison to a synthetic standard. At a dose of 21 mg 1,2-DMH/kg sc, approximately 14 and 11% of the dose were exhaled as AM and C02, respectively, in 24 hours. At 200 mg 1,2-DMH/kg, 23 and 4% of the dose appeared as AM and C02, respectively, in the respired -air within the same period. Most AM was seen in the first 6 hours, but the C02 evolution was more progressive, especially after the higher dose of 1,2-DMH.-J Natt Cancer Inst 56: 1271-1273, 1976.
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